1
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2
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- Used in clinical trials
- Might be used in clinical practice
- May aid physician to identify those with active disease
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3
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- Bath Ankylosing Spondylitis (BAS) scales
- BASDAI – Disease Activity Index
- BASFI – Functional Index
- BASGI – Global Index
- BASMI – Metrology Index
- BASRI – Radiographic Index
- Other measurement indexes
- SF-36 – 36-Item Medical Outcomes Study Short-Form Health Survey
- ASAS – Assessments in Ankylosing Spondylitis Working Group Improvement
Criteria
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4
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5
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- Self-administered questionaire
- Mean (VAS) of 10 questions:
- 8 of which relate to the functional anatomy of subjects
- 2 relate to a subject’s ability to cope with everyday life
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6
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- 1.) Putting on your socks or tights without help or aids (e.g sock aid).
|
7
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- 6.) Standing unsupported for ten minutes without discomfort?
|
8
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- The following VAS (0 to 10 cm) of subject self-assessments:
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9
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- 1.) How would you describe the overall level of fatigue/tiredness you
have experienced?
|
10
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- 4.) How would you describe the overall level of discomfort you have had
from any areas tender to touch or pressure?
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11
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- Represented as aggregate score (ranging from 0 to 10) using the
variables found in the following table
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12
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13
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14
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15
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- ASAS Response Criteria
- Patients will be categorized as an ASAS 20 responder if the patient
achieves the following:
- > 20% improvement from baseline and absolute baseline improvement
of > 10 (on a 0-100mm scale) in at least 3 of the following 4
domains:
- Patient global
- Spinal pain
- Function (BASFI)
- Inflammation
- No deterioration from the baseline (> 20% and absolute change of at
least 10 on a 0 to 100 mm scale) in the potential remaining domain
- ASAS Major Clinical Response
- Requires a value below 20 (scale of 0 to 100 mm) in each of the 4 ASAS
domains
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16
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- Patients will be categorized as in ASAS partial remission if the patient
achieves the following:
Value < 20 (0-100 scale) in all 4 domains of ASAS Working
Group Criteria for Improvement
- Patient global
- Spinal pain
- Function (BASFI)
- Inflammation
- average of the last 2 BASDAI questions concerning level and duration
of morning stiffness
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17
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|
18
|
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